In this work, we have investigated the effects of BCR::ABL1-mediated changes on expression of shelterin complex, TERT, telomerase RNA component (TERC) and dyskerin pseudouridine synthase 1 (DKC1) in CML cells including CD34+ primary cells isolated from peripheral blood or bone marrow of CML patients at different stages of disease. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.