Comparative analysis of the expression profile of genes of the telomere complex, such as TRF1, TRF2, POT1, RAP1, TTP1, TNKS1, and TNKS2 in CML-CP and CML-BP cells, showed a statistically significant increase in the expression of two genes: TNKS1 and RAP1 in CML-BP cells (p < 0.01) (Fig. 3a). Here, TNKS is linked to chronic myelogenous leukemia, BCR-ABL1 positive.