Whether the protein levels correlated with the mRNA levels of other potential growth factors (FGF1, 2, 3, 5, 9, 13, 16) mentioned in the TAC model, consistent with previous revealed, we found that protein levels of FGF2, FGF3, FGF13, and FGF16 were increased, whereas FGF1 and FGF9 were not significantly changed (Supplementary Fig. 1b). Here, FGF16 is linked to persistent truncus arteriosus.