In SUKSES-N3, 9/15 (60.0%) patients without prophylactic G-CSF had target-related grade ≥3 neutropenia, of whom 6 (40.0%) had febrile neutropenia, including 1 (6.7%) with septic shock due to pneumonia with grade 4 neutropenia [25]. This evidence concerns the gene CSF3 and neutropenia.