In the cancer cell dimension, we firstly established lung cancer cell lines expressing WT (LKB1-WT), mutated (kinase-dead mutation; LKB1-MUT), or no LKB1 (LKB1 control) (A549 and H460 cell lines, both of which exhibit the complete loss of LKB1) and performed RNA sequencing. The gene discussed is STK11; the disease is lung cancer.