We furtherly demonstrated that ICAM1 is an independent predictive biomarker in the NSCLC cohort using multivariate COX regression analysis (ICAM1: HR, 0.412; p = 0.013; PD-L1: HR, 0.405; p = 0.021; respectively; Supplementary Fig. 14D), while this was not observed in the melanoma cohort (ICAM1: HR, 0.693; p = 0.465; PD-L1: HR, 0.205; p = 0.001; Supplementary Fig. 14E). Here, CD274 is linked to melanoma.