CDK4/6 inhibition on tumor cells reinforced their interactions with T cells (Supplementary Fig. 17A); CDK4/6 inhibitors alone did not increase tumor cell apoptosis (Supplementary Fig. 17B), while co-culturing of CDK4/6 inhibitors pretreated tumor cells with NK-92 cells significantly increased apoptosis rate of tumor cells (Supplementary Fig. 17C), implying the potential value of CDK4/6 inhibitors in activating the immune microenvironment. Here, CDK4 is linked to neoplasm.