To fully demonstrate that ICAM1-mediated cancer cell-T-cell adhesion and interactions affects trafficking and activation of effector immune cells in LKB1-deficient NSCLC, we adoptively transferred congenitally-marked (APC+) stimulated CD8+ T cells expressing the OT-I, which is specific for OVA, into mice bearing Lkb1 proficient/deficient orthotopic lung tumors (LLC1-control-Icam1WT-OVA; LLC1-shLkb1-Icam1WT-OVA; LLC1-shLkb1-Icam1OE-OVA) and assessed OT-I cell infiltration and activation status in lung tumors (Fig. 3a). This evidence concerns the gene CD8A and non-small cell lung carcinoma.