The results of univariate and multivariate cox regression analyses showed that PIM1, PIM2, and PIM3 were all independent prognostic factors in DLBCL patients (Fig. 1D, E, PIM1: HR = 1.078 (1.019–1.315), PIM2: HR = 1.236 (1.057–1.969), PIM3: HR = 1.021 (1.002–1.211)). This evidence concerns the gene PIM2 and diffuse large B-cell lymphoma.