Compared with patients with normoglycemia and a low NT-proBNP level, the strongest numerical hazards for MACCEs and all-cause mortality were seen in patients with diabetes and NT-proBNP ≥ 336 pg/ml (HR 2.67, 95% CI: 1.83–3.89; HR 2.98, 95% CI: 1.48–6.00; Table 3, Fig. 5). This evidence concerns the gene NPPB and diabetes mellitus.