Furthermore, the analysis of gene expression profiles and of the mutational signatures from the GEO Dataset GSE42677 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE42677) of human cutaneous SCCs15,16 showed a striking inverse correlation between the TP53 and its modulator, ATM, and DIO2 expression in skin cancer progression (Pearson’s correlation coefficient, ρ: ρATM = 0.86; ρTP53 = 0.95; ρDIO2 = −0.93) (Fig. 1b, c). This evidence concerns the gene TP53 and skin cancer.