Thus, in the light of the present work and the previous data in the literature, we can state that, while in poor invasive and most benign tumors, like the BCC, the TH signal is attenuated and the predominant deiodinase is D360,61, more invasive tumors with a higher propensity to metastasize the TH and D2 levels are higher10,59. Here, DIO2 is linked to skin basal cell carcinoma.