It has also been demonstrated that irisin can reduce 78-kDa glucose-regulated protein (GRP78) and p-PERK/PERK protein expression levels, inhibits HG-induced oxidative stress in the endoplasmic reticulum, reduces myocardial hypertrophy, and thus have a cardioprotective effect [29]. The gene discussed is EIF2AK3; the disease is cardiac hypertrophy.