The left ventricular wall thickness and systolic function of a DCM mouse model showed that GRK2 mRNA levels and expression were significantly higher in 12-week-old diabetic mice than in 8-week-old diabetic mice, as were collagen volume fraction (CVF), collagen-3 expression, P53 expression, and apoptosis in the myocardium. This evidence concerns the gene GRK2 and familial dilated cardiomyopathy.