Sirtuin 3 (SIRT3) deficiency exacerbated hyperglycemia-induced mitochondrial damage, increased ROS accumulation, promoted necroptosis, activated the NLRP3 inflammasome, and ultimately worsened DCM in mice, as shown by Song et al. in an STZ-induced diabetic mouse model [47]. The gene discussed is NLRP3; the disease is familial dilated cardiomyopathy.