Tilianin and syringin were used together by Yao et al. to improve cardiac function in diabetic rats by lowering levels of diabetes/hyperglycemia-induced oxidative stress and regulating the TLR4/NF-κB/NLRP3 and PGC1/SIRT3/mitochondrial pathways [49]. The gene discussed is SIRT3; the disease is Hyperglycemia.