Neonatal Lupus Syndrome (NLE) is a condition associated with anti-SSA/RO antibodies that affect the fetal myocardium during pregnancy and can lead to dilated cardiomyopathy, endocardial fibroelastosis (EFE), congenital heart block (CHB), and skin, liver, and hematological system [1]. This evidence concerns the gene CALR and endocardial fibroelastosis.