TNNI3 and obesity due to melanocortin 4 receptor deficiency: However, univariate binary logistic regression revealed that overweight, obesity, cumulative dose of anthracycline > 350 mg/m2 and chest wall irradiation are the risk factors for the abnormal cTnI while only the cumulative dose of anthracycline > 350 mg/m2 is a risk factor for abnormal NT-proBNP.