The cumulative dose of anthracycline ≥ 350 mg/m2 (0R; 7.27, p < 0.001) followed by obesity (OR; 4.06, p < 0.01) and overweight (OR; 2.60, p < 0.01) also had significant associations with the occurrence of cardiotoxicity by means of elevation in cTnI. This evidence concerns the gene TNNI3 and obesity due to melanocortin 4 receptor deficiency.