In lung adenocarcinoma, Li found that YTHDF2 works as an oncogene by promoting AXIN1 mRNA decay and subsequently activating the Wnt/β-catenin pathway [10], nevertheless, Zhao reported that YTHDF2 serves as a tumor suppressor by regulating the TGFβ1/SMAD2/3 signaling pathway mediated by FAM83D (family with sequence similarity 83D) [11]. The gene discussed is YTHDF2; the disease is lung adenocarcinoma.