PRX and Charcot-Marie-Tooth disease type 4F: As one of the CMT subtypes, the occurrence and development of Charcot-Marie-Tooth disease type 4F (CMT4F) can be mainly attributed to the deletion and mutation of the periaxin gene located at 19q13, which causes nerve demyelination and its associated muscle atrophy at the distal end of the lower limb, especially the gastrocnemius muscle [4].