Among them, 14.3% of patients (4 of 28) had grade 3 or higher AEs, including 1 case of grade 4 decreased blood cell count, 1 case of grade 3 increased ALT/AST, 1 case of grade 3 fatigue and decreased appetite, and 1 case of grade 3 hypocalcaemia. This evidence concerns the gene GPT and Hypocalcemia.