TBK1 and arthritic joint disease: ,104 In addition, TBK1 regulates the early stages of autophagy as well as the TNF-induced RIPK1-dependent cell death.105, 106, 107 Homozygous loss-of-function mutations in TBK1 result primarily in a systemic autoinflammatory disorder characterized by variable neurological damage, arthritis and vasculitis.108