IKZF1 and Autoimmunity: Recently, heterozygous gain-of-function genetic variants in IKZF1 have been identified to cause a disorder characterized by IPEX-like immune dysregulation, including autoimmunity in the form of autoimmune cytopenias, vitiligo, type 1 diabetes, Hashimoto's thyroiditis and autoimmune hepatitis as well as gastrointestinal disease (inflammatory colitis and celiac disease), atopy and benign lymphoproliferation.63