Similar to Ikaros gain-of-function, loss-of-function, especially in case of haploinsufficiency, can also cause autoimmunity, in the form of autoimmune cytopenias, SLE, antiphospholipid syndrome (APS) and myasthenia gravis, which however, tends to localize at a single organ and is rather attributed to B cell dysregulation.64 The gene discussed is IKZF1; the disease is Autoimmunity.