T2D liability appeared to decrease, whilst CAD liability appeared to increase, apolipoprotein B, although estimates were imprecise for CAD; whilst liability to either disease appeared to decrease apolipoprotein A1 (T2D −0.03 SD; 95% CI −0.05 to −0.01; CAD −0.07 SD; 95% CI −0.11 to −0.03). The gene discussed is APOB; the disease is type 2 diabetes mellitus.