The experimental results showed that ginseng fat-soluble components negatively regulated EGFR, KDR, MAPK3, PTPN11, CTNNB1 protein levels in lung cancer NCI-H1299 and A549 cells; moreover, the protein expression in the high-concentration treatment group was significantly lower than in the low-concentration group. The gene discussed is EGFR; the disease is lung carcinoma.