Considering the role of CME and CavME in EGFR and Wnt signaling, our data (Figs. 2 and 3) yield an interesting hypothesis: the decline in the expression of caveolin-1 may be acting as a tumor suppressor whereas clathrin overexpression in progressive grades of prostate cancer may suggest a tumor promotion role through its regulation of Wnt signaling. The gene discussed is EGFR; the disease is Familial prostate cancer.