CAV1 and cancer: When a normal vs. cancer comparison was made for the expression of two proteins, there was a significant (p < 0.0001, Mann-Whitney) 2.5-fold increase in the expression of clathrin in prostate cancer tissue compared to corresponding controls (Fig. 2a); also, there was a concurrent and significant ~ 2.2 fold (p < 0.0001) decrease in the expression of caveolin-1 in prostate cancer tissue compared to normal tissue (Fig. 2b).