We further show that both clathrin and EGFR colocalize with the adaptor protein 2 (AP2), a marker for endocytotic clathrin complexes (Gaidarov et al. 1996), and there is no change in the interaction between caveolin-1 and EFGR but there is a significant increase in EGFR colocalization with clathrin in prostate cancer tissue compared to normal. This evidence concerns the gene EGFR and Familial prostate cancer.