CAV1 and cancer: Segregating samples according to different Gleason scores and comparing these against normal tissue show that (1) clathrin expression shows a decrease in score 3 + 4 and 4 + 3 but the expression reverts back up to the levels of 3 + 3 Gleason grade in high Gleason grade cancer (Fig. 4a) and (2) there is a gradual and persistent decrease in the expression of caveolin-1 with increasing Gleason score (Fig. 4b).