More and more studies show that pharmacological induction of HIF-1 is beneficial for the prevention of the progression of complications in the course of metabolic diseases such as diabetes (Sugahara et al. 2020; Dodd et al. 2018; Rojas et al.2018; Zhu et al. 2019; Zeinivand et al. 2020). Here, HIF1A is linked to diabetes mellitus.