Studies showed that observed in the course of diabetes, the decreased tissue glucose uptake, increased insulin resistance, and accelerated neuronal dysfunction are associated with the strong decline of Snca, Arc, and Npas4 genes expression levels (Micheli et al. 2021; Piatkowska-Chmiel et al. 2021; Hong et al. 2020). Here, NPAS4 is linked to diabetes mellitus.