Multiple studies have indicated that patients with T2DM have an increased incidence of alpha-synuclein (SNCA) accumulation, aggregation, and phosphorylation in both the pancreatic β cells and the brain (Martinez-Valbuena et al. 2018; Bassil et al. 2017) which favors by disturbed insulin signaling (Gao et al. 2015) and the fibrilization of amyloid-β and tau, two key proteins in Alzheimer’s disease (Twohig and Nielsen 2019). The gene discussed is SNCA; the disease is early-onset autosomal dominant Alzheimer disease.