The REIC/Dkk-3-induced reduction of PD-L1 was not limited to MDA-MB-231 cells; a similar reduction of PD-L1 was observed in pancreatic cancer BxPC-3 cells treated with REIC/Dkk-3 (50 μg/ml, 6 h) (Fig. 6d). Here, CD274 is linked to familial pancreatic carcinoma.