DKK3 and neoplasm: Bearing this in mind, we previously investigated the extracellular role of REIC/Dkk-3 and revealed that REIC/Dkk-3 plays a role in the differentiation of monocytes to dendritic-like cells, with the resulting dendritic-like cells contributing to tumor regression through their activation of cytotoxic T cells in vivo [2, 3].