The binding of REIC/Dkk-3 with Kremen enhances the cell-surface levels of low-density lipoprotein receptor-related protein 6 (LRP6), and thereby the LRP6-mediated signal is upregulated upon Wnt binding, eventually leading to enhanced CAF outgrowth and the mal-production of cancer preferential matrices. This evidence concerns the gene DKK3 and cancer.