Fig. S1), we decided to overexpress CXCR6 with or without REIC/Dkk-3 in different types of cancer cells (pancreatic cancer BxPC-3 cells, cervical cancer HeLa cells, and breast cancer MDA-MB-231 cells) (Fig. 2a). This evidence concerns the gene CXCR6 and familial pancreatic carcinoma.