Here, we examined COVID-19 single-cell RNA sequencing (scRNA seq) datasets from bronchoalveolar lavage (BAL) [47, 48], explant/post-mortem lung cells [49], and peripheral blood [50] and discovered that MALAT1 was negatively correlated with cell cycle progression and proliferation in CD4+ and CD8+ T cells of severe COVID-19 patients. This evidence concerns the gene MALAT1 and COVID-19.