HMOX1 and central nervous system cancer: Additionally, triggered by the tumor microenvironment,[43] the controlled release of TBTP‐Au from the reactive oxygen species (ROS)‐responsive nanosystem could initiate effective death of glioma cells through selectively binding to the overexpressed thioredoxin reductase (TrxR),[44, 45] and specifically activate HMOX1‐regulated ferroptosis pathway (Figure1A).