The SNP rs6794880 (chr3:84,402,361) in SRRM1P2 was reported to be related to obesity [47], and we suspected that this locus might influence the development of obesity through regulating the DNAm at one CpG (chr3:84,330,462) in SRRM1P2 we identified. Here, SRRM1P2 is linked to obesity due to melanocortin 4 receptor deficiency.