SIM1 and hypertensive disorder: As for DBP, several interesting genes were also found, including DAB2IP, WNT3A, GNA14, KCNT1, PGR, PLCH2, SIM1, and CNOT10. It was previously reported that the SNPs rs35061590 and rs13290547 in DAB2IP might be associated with heart rate [57] and hence might influence the pathogenesis of hypertension.