IRX1 and hypertensive disorder: It was indicated that the SNPs rs4841895 in COL5A1 [49], rs4799055 in NFATC1 (from dbGaP database), rs1449386 in CADM2 [50], and rs954767 in IRX1 [51] might play a role in blood pressure regulation, and we suspected that these loci might influence the development of hypertension through regulating the DNAm in these genes.