It was indicated that the SNPs rs4841895 in COL5A1 [49], rs4799055 in NFATC1 (from dbGaP database), rs1449386 in CADM2 [50], and rs954767 in IRX1 [51] might play a role in blood pressure regulation, and we suspected that these loci might influence the development of hypertension through regulating the DNAm in these genes. Here, COL5A1 is linked to hypertensive disorder.