Intriguingly, no sensitivity to loss of any of the other PAK family members was observed in CMS4 lines (Fig. 2A), neither to PAK2’s distant relatives PAK4–6, nor to its closer relatives PAK1 and PAK3, further highlighting the unique role of PAK2 in the mesenchymal CRC subtype. The gene discussed is PAK2; the disease is colorectal carcinoma.