PAK2 and colorectal carcinoma: To explore if loss of PAK2 would result in increased sensitivity to commonly used chemotherapy in CRC, CMS2 and CMS4 WT and PAK2 KO cultures were treated with 5-fluoruracil (5-FU) and Oxaliplatin, Deletion of PAK2 did not result in significantly increased response efficiency for either of the drugs, neither in CMS2 nor in CMS4 lines (Supplementary Fig. S2E, F).