Administration of STZ to class A scavenger receptor deficient mice (Sr-a−/−) results in a more severe version of diabetic retinopathy with increased inflammatory markers, including F4/80+ and CD64+ retinal populations and larger increases of pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6 or MCP-1, favoring an increase in pJNK/total JNK and pIκB/total IκB ratios, whereas pERK/total ERK ratio is reduced [119]. The gene discussed is MAPK8; the disease is diabetic retinopathy.