In addition, hyperglycemia enhances NF-κB signaling pathway—increased NF-κB and its co-activator PARP1 expression—and also promotes the overexpression of CXCL10 by neurons, microglia and astrocytes, and its receptor CXCR3, expressed by neurons and microglia [265]. This evidence concerns the gene PARP1 and Hyperglycemia.