Akimba mice show characteristic features of advanced stages of diabetic retinopathy, including neurodegenerative retina and decreased relative blood flow volume, accompanied by an augment in Iba1+/OX42+ microglia, as well as retinal infiltration of perivascular macrophages (F4/80+/CD14+) through a leaky BRB [249]. This evidence concerns the gene AIF1 and diabetic retinopathy.