Remarkably, gestational DM models have reported that the offspring from diabetic dams have a specific microglia signature characterized by overexpression of Iba1 and CD11b, overproduction of IL-1β, IL-6, TNF-α, increased NF-κB activation and decreased fractalkine/CX3CR1 signaling. This evidence concerns the gene NFKB1 and diabetes mellitus.