Likewise, CD11b labeling with OX42 increased in the hippocampus [85–87] and specifically in the hippocampal CA1 pyramidal area [88], as well as in the cortex and striatum [86, 89, 90], the pars nervosa of the pituitary [91], the hypothalamus, the basolateral amygdala [90] and the supraoptic nucleus [92] as diabetes progresses. Here, ITGAM is linked to diabetes mellitus.