A similar hypothalamic microglial phenotypic switch within time was described in another study in which HFD feeding for 3 days triggered overexpression of pro-inflammatory markers (Il1b, Il6 and Cd74), whereas 8 weeks on HFD resulted in a reduction in microglia-specific ‘sensing’ genes, including P2ry12, Selplg, Slc2a5 and Trem2, accompanied by increased expression of Pparg, compared to microglia from SCD-fed mice [149], which evidences the temporality and plasticity of microglial responses to obesogenic diet. Here, P2RY12 is linked to Schnyder corneal dystrophy.