TRPM7 and Hepatic failure: Additionally, the results from the blood analysis showed that endotoxin-treated AdVshTRPM7-infected rats were protected from the endotoxic-induced increases in plasma levels of aspartate aminotransferase (AST) (Fig. 10B), alanine aminotransferase (ALT) (Fig. 10D), and total bilirubin (TBIL) (Fig. 10F) level, observed in endotoxin-treated AdVCTRL-infected rats, indicating that TRPM7 is required for liver failure during endotoxemia.