It has been reported that the transient reception potential melastatin 7 (TRPM7) non-selective cation channel, which is permeable to divalent cations including Ca2+, is a key regulator of calcium permeability in ECs under conditions of endotoxin stimulation, promoting several deleterious actions, including cytokine production, endothelial fibrosis, kidney failure and mortality [27, 28]. Here, TRPM7 is linked to kidney failure.