Interestingly, the increased plasma levels of AST, ALT and TBIL in endotoxin-treated AdVCTRL-infected rats correlated with TRPM7 mRNA and protein expression (Fig. 10C, E and G respectively), supporting the notion that TRPM7 is associated with endotoxemia-induced liver failure. The gene discussed is TRPM7; the disease is serum lipopolysaccharide activity.