TRPM7 and serum lipopolysaccharide activity: To evaluate the participation of TRPM7 in neutrophils rolling on blood vessels in an in situ model, intravital imaging experiments were performed in mice subjected to endotoxemia by i.p. administration of 3 mg/kg endotoxin in the presence or absence of 80 mg/kg carvacrol 1 h after endotoxemia induction (Fig. 3A).