To determine whether TRPM7 regulates the procoagulant phenotype induced by endotoxemia, we tested in rats if adenoviral-mediated suppression of TRPM7 expression reduces crucial coagulation parameters after endotoxemia generation by i.p. administration of endotoxin, after which several coagulation parameters were measured (Fig. 9A). This evidence concerns the gene TRPM7 and serum lipopolysaccharide activity.