It is worth noting that even at 24 h post-dose, CRE-NP(α-M)-treated mice showed the strongest fluorescence signal and longest retention time of CRPPR-modified micelles in the tumor region, confirming that CRE-NP(α-M) improved tumor stromal barriers through CAFs and collagen downregulation, enhancing the distribution of CRP-MC in tumors. This evidence concerns the gene CRP and neoplasm.