Feng et al. developed CAFs-targeted biodegradable polymer nanoparticles (CRE-NP (α-M), modified with CREKA peptide and loaded with traditional Chinese medicine (TCM) α-mangostin (α-M), which efficiently delivered α-M to tumor tissues by CREKA specific recognition of overexpressed fibronectin on CAFs, and then modulated the tumor microenvironment by interfering with the TGF-β/SMAD signaling pathway by α-M. The gene discussed is FN1; the disease is neoplasm.