Taken together, these data indicated that Baicalein induced DNMT1-dependent demethylation of the SHP-1 promoter region, and subsequently activated SHP-1 expression, which resulted in an inhibition of JAK2/STAT5 signaling in resistant CML CD34+ cells. Here, PTPN6 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.