PTPN6 and chronic myelogenous leukemia, BCR-ABL1 positive: Our results showed that BM microenvironment-derived hBMSCs contributed to CML CD34+ cells resistance to IM via activating JAK2/STAT5 signaling, and Baicalein provided a promising strategy for reversing it by enhancing DNMT1-dependent demethylation of the SHP-1.