CD34 and chronic myelogenous leukemia, BCR-ABL1 positive: After administration with IM(0, 0.125, 0.25, 0.5 μM) for 36 h, the apoptosis rate of K562 CD34+ cells or primary CML CD34 + cells was markedly reduced in co-culture than in monolayer culture (Fig. 1A, B).