The ARID1A-KD cell line was constructed using the human EGFR mutant LUAD cell line (HCC4006), and the evaluation of the knockdown effect is displayed in Fig. 1F. The phenotypic changes in the proliferation, migration and invasion of ARID1A-KD cells compared with NC cells are displayed in Fig. 2A, B. The 490 nm OD value of live cells in the ARID1A KD group was higher than that in the NC group after cell incubation for 24 h (P = 0.0042) and 48 h (P = 0.0005), which suggested the enhancement of tumor cell proliferation in ARID1A-KD cells (Fig. 2A). This evidence concerns the gene ARID1A and neoplasm.