Indeed miR-125b, as an onco-miR, targets tumor suppressors including long non-coding RNA named insulin-like growth factor 1 receptor antisense imprinted non-protein coding RNA (IRAIN) and PH domain and leucine-rich repeat protein phosphatase 2 (PHLPP2) that finally elevates AKT signaling pathway and myeloma cell progression [20, 21]. Here, IRAIN is linked to plasma cell myeloma.