Due to the high expression of miR-125b in EVs [25], its up-regulation in serum associated with Rituximab, Cyclophosphamide, Hydroxy daunorubicin, Vincristine, and Prednisone (R-CHOP) resistance, further relapse, and diminished survival in diffuse large B cell lymphoma patients [26]. This evidence concerns the gene DDIT3 and diffuse large B-cell lymphoma.