As A549 is a TP53 wild-type cell line and NCI-H1299 is a TP53-null cell line, the similar effects of RPL11 overexpression or knockdown on A549 and NCI-H1299 growth indicated that, unlike other cancer types, RPL11 might regulate NSCLC cell growth in a TP53 independent way. The gene discussed is TP53; the disease is cancer.