The results of RPL11 expression in NSCLC cell lines, RPL11 effects in NSCLC cells proliferation viability, migration, ERS, and autophagy using NSCLC cell lines, suggested that RPL11 promotes NSCLC cells proliferation and migration by regulating endoplasmic reticulum stress and cell autophagy. The gene discussed is RPL11; the disease is non-small cell lung carcinoma.