A significant median decrease was observed in the number of TILs after irradiation compared with the amount before irradiation in 22 patients (CD3+ 69%, p = 0.002; CD4+ 27%, p = 0.003; CD8+ 74%, p = 0.004).63 The decreased amount of TILs could be explained by the low number of vital tumor cells in low-risk patients with small breast tumors. This evidence concerns the gene CD4 and breast neoplasm.