Interestingly, 23 of the 75 hub genes from CD56+ CTC, such as ERBB2, TP53, CREBBP and NF1, were found enriched in at least 1 of the 3 queried databases, illustrating the high affinity of the liquid biopsies to recapitulate the molecular genomic landscape of small cell lung cancer. This evidence concerns the gene CREBBP and small cell lung carcinoma.