Although the physiological and pathological function of OPN3 has been performed in many aspects, such as melanocyte apoptosis24, skin pigmentation regulation25,26,28, and even joining in the skin tumor progress29, whether OPN3 can participate in and regulate the formation of melanin caps in keratinocytes under UV irradiation needs further elucidation. The gene discussed is OPN3; the disease is skin neoplasm.