First, habitually skipping breakfast was associated with elevated concentrations of CRP.14 Long-term low-grade inflammation promotes tumor development and progression via (1) oxidation32; (2) mutation, DNA methylation and posttranslational variations caused by inflammatory response mediators, including cytokines, free radicals, prostaglandins and growth factors32; and (3) the activation of the NF-κB pathway, which is essential for the invasion of cancer.33 Second, breakfast consumption lowers the risk of obesity and metabolic risk factors. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.