In addition, miR-182-5p, miR-20a-5p and miR-92a-3p had at least 2 putative gene targets within the transcriptome of lesional human CA NVUs25,36, related to enriched-KEGG pathways with documented mechanistic role in the physiopathogenesis of CAs including HIF-1, MAPK, PI3K-Akt, Rap1 and VEGF signaling20–22,54. Here, VEGFA is linked to cancer.