In the case of developmental disorders, a variety of congenital neurological diseases are caused by multiple genetic deletions in the choroid plexus and can cause severe hydrocephalus or other problems24,25; furthermore, in the pathological process of AD, studies have confirmed that B-CSFB function gradually decreases with age, and improving B-CSFB function can reduce the content of Aβ or tau proteins in CSF26. The gene discussed is MAPT; the disease is Alzheimer disease.