In contrast to the results in immunocompetent mice in which B7-H3 knockdown strongly suppresses tumor cell growth, B7-H3 knockdown and control cells have similar tumor growth kinetics in Rag1−/− mice (Fig. 5d, e), thus implicating adaptive immunity as the main mechanism of B7-H3-mediated effects on tumor growth in cells with hyperactive mTORC1. This evidence concerns the gene RAG1 and neoplasm.