Depleting either CD8+ T cells or CD4+ T cells significantly increased tumor volume in the cells with B7-H3 shRNAs (Fig. 7b, c and Supplementary Fig. 6a, b), but to our surprise, depletion of CD4+ T cells increased tumor growth more than depletion of CD8+ T cells (Fig. 7b, c), despite similar efficacy of depletion (>99% in both spleens and tumors) (Supplementary Fig. 6c, d). Here, CD276 is linked to neoplasm.