In vivo, the results were strikingly different: after s.c. inoculation of B7-H3 knockdown or control 105K cells into wild-type (WT) syngeneic C57BL/6 J mice, B7-H3 inhibition suppressed tumor growth by at least 80% (p < 0.0001) (Fig. 5a, b) and markedly increased the tumor-free survival (p < 0.0001) (Fig. 5c). Here, CD276 is linked to neoplasm.