In support, pre-incubation of CLL cells with the low-affinity α-GalCer analog OCH, which loads at the cell surface and thereby bypasses the intracellular loading machinery,36 enabled the CD1d-Vδ2 hu-bsTCE to induce type 1 NKT cell degranulation, cytokine production, and cytotoxicity toward patient-derived CLL cells (Figure 5F). The gene discussed is CD1D; the disease is B-cell chronic lymphocytic leukemia.