Since we previously showed that VHH1D12-induced type 1 NKT cell activation critically depended on the presence of (weakly) agonistic glycolipid Ag in CD1d,23 we hypothesized that CLL cells could differ from MM and AML cells in the amount and/or type of glycolipid Ag loaded in CD1d. Here, CD1D is linked to Miyoshi myopathy.