However, pre-incubation of CLL cells with thapsigargin, previously shown to induce ER stress and trigger type 1 NKT activation,33,34 did not enhance type 1 NKT cell degranulation or CLL lysis (Figure S4H), indicating that CLL cells might be impaired in their ability to load endogenous agonistic lipid Ag despite (induction of) ER stress. The gene discussed is SGCG; the disease is B-cell chronic lymphocytic leukemia.