In co-cultures of BMMCs or PBMCs from patients with MM, monocytic AML, or CLL and expanded healthy donor-derived type 1 NKT, Vγ9Vδ2-T, or a mixture (1:1) thereof, CD1d-Vδ2 hu-bsTCE induced robust type 1 NKT and/or Vγ9Vδ2-T cell degranulation and cytokine production; for type 1 NKT cells, both Th1 (TNF, IFN-γ, some IL-2) and Th2 type cytokines (IL-4, IL-10); for Vγ9Vδ2-T cells predominantly Th1 type cytokines (TNF, IFN-γ, some IL-2) (Figures 5C–5E and S4B–S4D). Here, TNF is linked to B-cell chronic lymphocytic leukemia.