DSP and ventricular tachycardia: In a patient diagnosed with ACM and experiencing monomorphic ventricular tachycardia, abnormal repolarization, and akinesia of the right ventricular apex (Table S1), we identified a novel missense mutation within the DSP gene (c.3562T>C) that translates to an amino acid substitution of a conserved tyrosine to a histidine (p.Tyr1188His; Figures 1A and 1B).