These 221 genes were subsequently evaluated against a previously published late-onset AD transcriptome, in which the dorsolateral prefrontal cortex was profiled at bulk tissue level (4), revealing a subgroup of 53 genes directly regulated by CREB3L2-ATF4 with disease-associated differential expression (significance cutoff defined as P < 1 × 10−15; Fig. 4B and fig. The gene discussed is CREB3L2; the disease is Alzheimer disease.