These included in their vicinity ABCA7, ADAM10, ADAMTS1, BCKDK, BIN1, CELF1, CSTF1, CD2AP, EED, FERMT2, HESX1, IQCK, KAT8, MEF2C, PICALM, PSMC3, OARD1, and ZCWPW1, many of which directly relate to AD susceptibility through their impact on the endocytic pathway and amyloid beta percursor protein (APP) homeostasis (Fig. 3C and fig. The gene discussed is PICALM; the disease is Alzheimer disease.