In any case, we found an equally high, statistically significant degree of interaction between the CREB3L2-ATF4 network and down-regulated DEGs in inhibitory cells (59.8%; representation factor = 1.6, P < 0.001, hypergeometric test), suggesting a role for CREB3L2-ATF4 in promoting gene repression in AD neurons. Here, CREB3L2 is linked to Alzheimer disease.