Up-regulated DEGs also showed appreciable levels of overlap with CREB3L2-ATF4 and its wider network (43.5%; representation factor = 1.2, P < 0.031, hypergeometric test), but note that gene repression constitutes 74.7% of the expression signature of these cells in AD (n = 565 of 756; fig. Here, CREB3L2 is linked to Alzheimer disease.