In any case, we found an equally high, statistically significant degree of interaction between the CREB3L2-ATF4 network and down-regulated DEGs in inhibitory cells (59.8%; representation factor = 1.6, P < 0.001, hypergeometric test), suggesting a role for CREB3L2-ATF4 in promoting gene repression in AD neurons. This evidence concerns the gene ATF4 and Alzheimer disease.