In addition, four up-regulated TFs—NFE2L2 (commonly known as NRF2; P = 9.09 × 10−30), SOX9 (P = 2.24 × 10−27), NFATC1 (P = 4.74 × 10−21), and MXD4 (P = 6.16 × 10−15)—were part of the AD-associated transcriptional program specifically mediated by CREB3L2-ATF4 (Fig. 4B and fig. This evidence concerns the gene CREB3L2 and Alzheimer disease.