MAPK8 and neuroblastoma: By investigating the impact of gene expression noise on the components of the chemotherapy-induced JNK network in neuroblastoma cells, we have now shown that the HDAC inhibitor vorinostat can restore JNK activity to otherwise apoptotic-impaired cells and that BH3 mimetics can increase sensitivity to chemotherapy by lowering the single-cell apoptotic threshold set by the downstream antiapoptotic proteins MCL-1 and BCL-2.