MAP2K4 and neuroblastoma: Using the NB69 (high JNK activating), SH-SY5Y (moderate JNK activating), and SK-N-AS (low JNK activating) neuroblastoma cell lines (Fig. 2C), we can again demonstrate this function of the model by using the relative expression levels of JNK, MKK4, MKK7, ZAK, and phospho-Akt in these cell lines as parameters within our model.