We observed no significant difference in clinical characteristics between the patients with wild-type BRAF and the patients with variant BRAF. Among the patients with variant BRAF, the patients with BRAF V600E variants were more likely than those with non-V600E BRAF variants to have large tumor size (10 of 13 [77%] vs 12 of 36 [33%]; P = .007), multiple tumors (7 of 13 [54%] vs 8 of 36 [22%]; P = .04), and more vascular/bile duct invasion (7 of 13 [54%] vs 8 of 36 [22%]; P = .04). This evidence concerns the gene BRAF and neoplasm.