BRAF and intrahepatic cholangiocarcinoma: We further noted the association between BRAF variants and OS using genomic data of 514 ICC samples from 2 studies in cBioPortal.8,21,22 Kaplan-Meier analysis showed that BRAF V600E variants, but not overall BRAF variants or non-V600E BRAF variants, were associated with inferior OS (median OS, 15.8; 95% CI, 2.7-28.9 months vs 28.3; 95% CI, 24.4-32.1 months; P = .04) compared with wild-type BRAF (eFigure 2 in Supplement 1).