The overall frequency of BRAF variance in our cohort was 4.2%, which is similar to that in The Cancer Genome Atlas (3.3%), Memorial Sloan Kettering 2017 (4.4%), and Memorial Sloan Kettering 2021 (6.3%) cohorts.22,23,24 To our knowledge, no study has investigated BRAF variant subtypes and classes in ICC, perhaps because of the limited sample size. Here, BRAF is linked to intrahepatic cholangiocarcinoma.