The tumor microenvironment (TME) was histologically graded for inflammation phenotype, and changes were assessed in CD8+ cell density, FoxP3+ cell density, CD8+/GZMB+ cell density, HPV16 E6 and E7 transcript levels, PD-L1 and MHC-I presence on tumor cells (Figs. 3 and 4; Supplementary Figs. S4–S9). This evidence concerns the gene CD8A and neoplasm.