Analyses of the day 28 biopsy showed increased CD8+ and FoxP3+ cell densities and an increase in CD8+ GZMB+ T cells in conjunction with increased MHC-I (HLA-A) expression characterizing a shift in the tumor microenvironment to an inflamed phenotype conducive to tumor cell killing rather than immune evasion. The gene discussed is CD8A; the disease is neoplasm.