The relationship between periodontal disease and COVID-19 has been explained by many possible pathological pathways such as having common risk factors, having similar cytokine pathways in the chronic inflammatory response, an increase in blood biomarkers, such as WBC and hs-CRP in both diseases, and ACE-2 secretion which is required for virus load in oral epithelial cells [3, 6, 14]. The gene discussed is ACE2; the disease is COVID-19.