The intersection targets were mainly enriched in processes like muscle cell proliferation, membrane raft, cytokine receptor binding, and signaling pathways such as the AGE-RAGE signaling pathway in diabetic complications, lipid, and atherosclerosis, TNF signaling pathway, etc. AGE-RAGE signaling pathway can trigger a series of inflammation, leading to islet cell damage and insulin resistance, which is tightly correlated with the occurrence of kidney-related diseases [35]. Here, TNF is linked to Insulin resistance.