Accumulation of MAP1B and TBCB proteins can disrupt the movement of motor proteins and may affect transport processes by altering microtubule dynamics, which leads to morphological and functional changes in the neurofilament network, distension and demyelination of axonal fibers, cell death, and subsequently neurodegenerative disorders such as giant axonal neuropathy (Allen et al., 2005; Bomont et al., 2000; Wang et al., 2005; Xu et al., 2020). The gene discussed is TBCB; the disease is giant axonal neuropathy.