DNMT3A and chronic myelogenous leukemia, BCR-ABL1 positive: Correspondingly, the dCAS9-DNMT3a-targeting RAGE promoter region partially blocked the CML/CEL-mediated augment of RAGE expression (Figures 4D, E), while the scrambled sgRNA with dCAS9-DNMT3a exhibited no effect on RAGE expression (Supplementary Figure S1).