To clarify whether the activation of NF-κB and STAT3 is the sole modulation for CML/CEL-mediated RAGE upregulation, niclosamide and QNZ, widely used STAT3 and NF-κB specific inhibitors, were used to see if it could completely block the effect produced by these AGEs. This evidence concerns the gene NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive.