Overexpression of EZH2 (Enhancer of zeste homolog 2), a member of the polycomb proteins which is responsible for the tri-methylation of H3k27 and inactive chromatin state, is a marker of cancer initiation, progression, metastasis and targeted therapy (Chase and Cross, 2011; Duan et al., 2020). This evidence concerns the gene EZH2 and cancer.