Aberrant active demethylation and increased 5hmC marker at TOP2A and EZH2 genes were associated with poor prognosis in an aggressive subtype of prostate cancer and are related to the activation of oncogenic pathways, such as MYC and E2F, and TGFβ signaling pathways in metastatic castration-resistant prostate cancer (Palanca-Ballester et al., 2021). This evidence concerns the gene TOP2A and Familial prostate cancer.