RB1 and cancer: Among these, genes related to cell cycle progression (e.g., RB1, CDKN2A and CDKN2B), invasion and metastasis (e.g., CDH1 and CDH13) and apoptotic signaling (e.g., DAPK1) are hypermethylated in several cancers (Zafon et al., 2019; Nishiyama and Nakanishi, 2021).