CD8A and neoplasm: A new study showed that CD8+ T cells in the tumour micro-environment not only induce cell death in the traditional way (perforin/granzyme pathway and Fas/Fas ligand-pathway), but also down-regulate SLC3A2 and SLC7A11 expression by secreting IFN to induce ferroptosis.10 Moreover, prostaglandin E2 (PGE2) has attracted widespread attention as an important immunomodulator.