TGS1 and obesity due to melanocortin 4 receptor deficiency: We observed that the levels of PIMT protein were increased in the livers of two obesity-associated T2D mouse models: ob/ob mice (Figures 1A and 1B) and wild-type (C57BL/6) mice fed with the high-fat diet (HFD) (Figures 1D and 1E) compared with the wild-type and control diet-fed mice, respectively.